Read the December Issue of Cancer Medicine Online Now!

Cancer Medicine

Issue 2:6 of Cancer Medicine is live and available to read online.  A great range of articles in this collection, but here are some top articles which Editor-in-Chief Prof. Qingyi Wei has highlighted from the issue:

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Phenotypic modifications in ovarian cancer stem cells following Paclitaxel treatment
Vinicius Craveiro, Yang Yang-Hartwich, Jennie C. Holmberg, Natalia J. Sumi, John Pizzonia, Brian Griffin, Sabrina K. Gill, Dan-Arin Silasi, Masoud Azodi, Thomas Rutherford, Ayesha B. Alvero and Gil Mor

Summary: We demonstrate that putative ovarian cancer cells with tumor initiating capacity that survive chemotherapy acquire molecular phenotypic modifications, which makes them distinct from the original tumor-initiating cells. The modifications that occur may not be the same in every patient. This suggests that treatment modalities should be modified to each individual patient. Further studies using our models will identify biomarkers for personalized treatment.

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ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC
Pachiyappan Kamarajan, Jae M Shin, Xu Qian, Bibiana Matte, Joey Yizhou Zhu and Yvonne L. Kapila

Summary: Our data demonstrate, for the first time that CD44 cleavage by ADAM17 is a critical determinant of orasphere formation or stemness and tumorigenesis in oral cancer. Our data support the concept that therapeutics that target CD44 cleavage mechanisms within the stem cell compartment can impair stemness and thus hold promise for treating aggressive oral cancer.

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BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1
Helen Jayne Susan Stewart, Gillian Abigail Horne, Sarah Bastow and Timothy James Telfer Chevassut

Summary: The bromodomain inhibitor JQ1 blocks BRD4 binding to acetylated histones leading to apoptosis of acute myeloid leukemia cells. We find JQ1 exhibits synergistic activity with histone deacetylase inhibitors, Nutlin-3 and daunorubicin suggesting involvement of p53. We show that BRD4 interacts with p53, suggesting a role in DNA damage repair response that is disrupted by JQ1 in DNMT3A/NPM1-mutated OCI-AML3 leukemia cells.

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Read the Latest Highlights from Cancer Medicine

Cancer Medicine

Cancer Medicine Issue 2:5 is online and avilable to read now!

The journal brings together articles on a range of oncology specialties, covering cancer biology, clinical cancer research and cancer prevention, with authors from across the globe.  The journal is fully open access so all of our articles are freely immediately available to read, download and share. 

You can access all our content here.

Below are some top articles which Editor-in-Chief Prof. Qingyi Wei has highlighted from the October issue. 

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Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNF?-mediated apoptosis
Bethanie L. Morrison, Michael E. Mullendore, Luke H. Stockwin, Suzanne Borgel, Melinda G. Hollingshead and Dianne L. Newton

Summary: The mechanistic basis for oxyphenisatin acetate anti-cancer activity remains unresolved. This study demonstrates that exposure is associated with an acute nutrient deprivation response leading to translation inhibition, induction of autophagy, transient estrogen receptor (ER) stress and mitochondrial dysfunction. Ultimately these effects promote apoptosis induction, which in ER+ breast cancer cells is mediated by autocrine TNF? production. This is the first study implicating a nutrient deprivation response as central to the downstream effects of oxyphenisatin acetate.

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Treatment with the vascular disruptive agent OXi4503 induces an immediate and widespread epithelial to mesenchymal transition in the surviving tumor
Theodora Fifis, Linh Nguyen, Cathy Malcontenti-Wilson, Lie Sam Chan, Patricia Luiza Nunes Costa, Jurstine Daruwalla, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Mark Waltham, Erik W. Thompson and Christopher Christophi

Summary: Vascular disruptive treatments effectively destroy over 90% of solid tumors with minimal effects on host tissues but a viable rim of cells persists in the tumor periphery that leads to recurrence. An immediate and widespread epithelial to mesenchymal transition (EMT) occurs within the viable rim after treatment that may be responsible for this resistance to treatment. Targeting EMT in combination with vascular disruptive agents or other therapies in the clinic may improve treatment outcomes.

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Preimmunization of donor lymphocytes enhances antitumor immunity of autologous hematopoietic stem cell transplantation
Koji Suzuki, Kouichirou Aida, Reina Miyakawa, Kenta Narumi, Takeshi Udagawa, Teruhiko Yoshida, Yusei Ohshima and Kazunori Aoki

Summary: Autologous hematopoietic stem cell transplantation (HSCT) can create an environment strongly supporting the enhancement of antitumor immunity. However, it was rare to cure tumor-bearing mice. We showed that the pre-immunization of donor lymphocytes by intratumoral interferon alpha gene transfer was highly effective in enhancing the antitumor immunity of HSCT and eradicated tumors.

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Read the Latest Highlights From Food Science & Nutrition

Food Science & Nutrition CoverTake a look at the latest highlights from Food Science & Nutrition below.  Editor-in-Chief Dr Y. Martin Lo has selected his favourite articles from the past two issues. 

The journal publishes articles relating to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.  Food Science & Nutrition is an open access, fully peer-reviewed journal providing rapid dissemination of research in all areas of food science and nutrition.

Access our full catalogue of content here>

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Quality assessment of butter cookies applying multispectral imaging
Mette S. Andresen, Bjørn S. Dissing and Hanne Løje

Summary: Multi-spectral image analysis is applied to quantify selected quality aspects of a cookie product.

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Flaking process increases the NF-?B inhibition activity and melanoidin extractability of coffee
Yi-Fang Chu, Kang Hu, Thomas Hatzold, Richard M. Black and Don Chen

Summary: Recent developments to improve the efficiency and extractability in coffee brewing have prompted the use of flaking technique in manufacturing roast and ground coffee products. Our study provides an initial insight into the effect of flaking in increasing melanoidin content in the extract, thus leading to elevated melanoidin-associated inhibition of NF-?B activation.

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Analyzing comprehensive palatability of cheese products by multivariate regression to its subdomains
Kumiko Nakano, Yasushi Kyutoku, Minako Sawa, Shigenobu Matsumura, Ippeita Dan and Tohru Fushiki

Summary: A novel sensory evaluation instrument for describing food palatability was explored. Four factors contributing to comprehensive palatability were hypothetically extracted.

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MicrobiologyOpen Publishes Issue 2:3

MicrobiologyOpenYou can read Issue 2:3 of MicrobiologyOpen online now!

MicrobiologyOpen is a broad scope, peer reviewed journal delivering rapid decisions and fast publication of microbial science.  The journal gives priority to reports of quality research, pure or applied, that further our understanding of microbial interactions and microbial processes.

Editor-in-Chief, Pierre Cornelis has highlighted the papers below from the latest issue:

purple_lock_openTruncation of type IV pilin induces mucoidy in Pseudomonas aeruginosa strain PAO579
T. Ryan Withers, F. Heath Damron, Yeshi Yin and Hongwei D. Yu

Summary: Schematic diagram of summarizing the induction of alginate production and mucoid conversion by PilA in Pseudomonas aeruginosa strain PAO579. The sigma factor RpoN is required for transcription of pilA108 and algW. PilA108 is transported to the periplasm where it activates the periplasmic protease AlgW which proteolytically degrades the anti-sigma factor MucA releasing the sequestered sigma factor AlgU.

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A novel l-isoleucine-4?-dioxygenase and l-isoleucine dihydroxylation cascade in Pantoea ananatis
Sergey V. Smirnov, Pavel M. Sokolov, Veronika A. Kotlyarova, Natalya N. Samsonova, Tomohiro Kodera, Masakazu Sugiyama, Takayoshi Torii, Makoto Hibi, Sakayu Shimizu, Kenzo Yokozeki and Jun Ogawa

Summary: The genes encoding HilA and HilB from Pantoea ananatis AJ13355 were cloned and expressed in Escherichia coli. The culturing of E. coli cells expressing hilA (E. coli-HilA) or both hilA and hilB (E. coli-HilAB) in the presence of l-isoleucine resulted in the conversion of l-isoleucine into two novel biogenic compounds: l-4?-isoleucine and l-4,4?-dihydroxyisoleucine, respectively. In parallel, two novel enzymatic activities were detected in the crude cell lysates of the E. coli-HilA and E. coli-HilAB strains: l-isoleucine-4?-dioxygenase (HilA) and l-4?-hydroxyisoleucine-4-dioxygenase (HilB) activities, respectively.

purple_lock_openUbiquitination dynamics in the early-branching eukaryote Giardia intestinalis
Carlos A. Niño, Jenny Chaparro, Paolo Soffientini, Simona Polo and Moises Wasserman

Summary: Ubiquitation is an active and dynamic process in Giardia. Different types of ubiquitin modifications are present in this ancestral unicellular eukaryote and vary in terms of temporal and spatial distribution from trophozoites to cyst maturation. Using a proteomics approach, we identified around 200 high-confidence ubiquitinated candidates that vary their ubiquitination status during differentiation.

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Read the June Issue of Cancer Medicine Online Now!

Cancer Medicine

Issue 2:3 of Cancer Medicine is live and available to read online

The journal brings together articles on a range of oncology specialties, covering cancer biology, clinical cancer research and cancer prevention, with authors from across the globe.

Below are some top articles which Editor-in-Chief Prof. Qingyi Wei has highlighted from the issue.  We hope that you enjoy this exciting new content.

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Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab
Timothy J. Price, Jennifer E. Hardingham, Chee K. Lee, Amanda R. Townsend, Joseph W. Wrin, Kate Wilson, Andrew Weickhardt, Robert J. Simes, Carmel Murone and Niall C. Tebbutt

Summary: Phosphatase and tensin homologue (PTEN) remains controversial as a predictive and prognostic marker. There also remains uncertainty as to the best method to assess PTEN status. Here, we use PTEN copy number and assess the association of outcome and PTEN loss, as defined by copy number variation.

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A contemporary analysis of morbidity and outcomes in cytoreduction/hyperthermic intraperitoneal chemoperfusion
Michelle Haslinger, Valerie Francescutti, Kristopher Attwood, Judith Andrea McCart, Marwan Fakih, John M. Kane III and Joseph J. Skitzki

Summary: In the contemporary setting, cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CS/HIPEC) are associated with a low mortality and improved survival. When present, complications are associated with a decreased overall survival. This treatment modality should be considered within the context of multidisciplinary care for select peritoneal carcinomatosis patients.

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Comparison of the accuracy of Hybrid Capture II and polymerase chain reaction in detecting clinically important cervical dysplasia: a systematic review and meta-analysis
Hung N. Luu, Kristina R. Dahlstrom, Patricia Dolan Mullen, Helena M. VonVille and Michael E. Scheurer

Summary: The selection of a screening test is important to detect clinically relevant cases of Human papillomavirus (HPV) infection while avoiding the unnecessary cost, stress and compromise of the cervix to patients associated with over-treating mild cytological abnormalities. Given the clinical relevance and importance of cervical cancer worldwide, our results support the use of Hybrid Capture II (HCII) in cervical screening programs.

Cancer Medicine is a peer reviewed, interdisciplinary journal providing rapid publication of cutting-edge research from global biomedical researchers across the cancer sciences.

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Food Science & Nutrition Publishes Issue 1:3

Food Science & Nutrition CoverYou can read Issue 1:3 of Food Science & Nutrition online now!

The journal publishes articles relating to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.  Food Science & Nutrition is an open access, fully peer-reviewed journal providing rapid dissemination of research in all areas of food science and nutrition. 

This issue features an exciting range of articles, including the highlights below, selected by Editor-in-Chief Dr. Y. Martin Lo.

purple_lock_openRoyal jelly enhances antigen-specific mucosal IgA response
Hikaru Kai, Yuji Motomura, Shiro Saito, Ken Hashimoto, Tomoki Tatefuji, Nobutoki Takamune and Shogo Misumi

Summary: Royal Jelly exhibits mucosal immunomodulatory properties via stimulation of effective uptake of antigens through M cells.

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Microbial contribution to spoilage of African breadfruit (Artocarpus communis, Forst) during storage
Olusegun B. Ajayi and Tinuola T. Adebolu

Summary: African breadfruit morphological changes during spoilage. Spoilage organism (bacteria and fungi) were responsible for spoilage.

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Functional properties of Ditaxis heterantha proteins
Ma T. Espino-Sevilla, Maria E. Jaramillo-Flores, Rodolfo Hernández-Gutiérrez, Juan C. Mateos-Díaz, Hugo Espinosa-Andrews, Ana P. Barba de la Rosa, Jose O. Rodiles-López, Socorro Villanueva-Rodríguez and Eugenia C. Lugo-Cervantes
 
Summary: Differential scanning calorimetry (DSC) thermograms of protein fractions from Ditaxis heterantha.
 

Issue 2:2 of Cancer Medicine now live!

Cancer Medicine

You can read Issue 2:2 of Cancer Medicine online now!

The journal brings together articles on a range of oncology specialties, covering cancer biology, clinical cancer research and cancer prevention, with authors from across the globe.

Below are some top articles which Editor-in-Chief Prof. Qingyi Wei has highlighted from the issue.  We hope that you enjoy this exciting new content.

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GM-CSF enhances tumor invasion by elevated MMP-2, -9, and -26 expression
Claudia M. Gutschalk, Archana K. Yanamandra, Nina Linde, Alice Meides, Sofia Depner and Margareta M. Mueller

Summary: In this study we analyze the contribution of granulocyte–macrophage colony-stimulating factor (GM-CSF) to tumor invasion and proteinase expression and activation in HT-29 colon adenocarcinoma cells. We could demonstrate that GM-CSF contributes to tumor progression, enhancing the migratory capacity in vitro and tumor cell invasion into the surrounding tissue and stromal activation such as angiogenesis in vivo. Moreover, in a complex 3D in vitro model, GM-CSF overexpression or treatment was associated with a discontinued basement membrane deposition that might be mediated by the observed increased expression and activation of MMP-2, -9, and -26.

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Complexity in cancer biology: is systems biology the answer?
Evangelia Koutsogiannouli, Athanasios G. Papavassiliou and Nikolaos A. Papanikolaou

Summary: Tumor tissues consist of different types of cells with altered genetic, epigenetic, and protein networks. We propose a simple conceptual model to account for oncogenic and tumor suppressor proteins forming different complexes within and between tumor cells.

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Is there a role for immune checkpoint blockade with ipilimumab in prostate cancer?
Edward Cha and Eric J. Small

Summary: Ipilimumab, a cytotoxic T-lymphocyte antigen 4 (CTLA-4)-blocking monoclonal antibody, is thought to augment natural immune responses to tumors. Ipilimumab is approved in several countries to treat advanced melanoma, and it is now under phase 3 investigation in prostate cancer based on the results of 7 smaller clinical trials, as reviewed in this article.

Cancer Medicine is a peer reviewed, interdisciplinary journal providing rapid publication of cutting-edge research from global biomedical researchers across the cancer sciences.

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Read Issue 2:2 of MicrobiologyOpen Now!

MicrobiologyOpenThe latest issue of MicrobiologyOpen is available online now! 12 new articles are fully open access: free to read, download and share.

Below are some recent top articles highlighted by the Editor-in-Chief, Pierre Cornelis:

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Summary: In this review, we synthesize the various methods available for topological mapping of ?-helical integral membrane proteins to provide investigators with a comprehensive reference for choosing techniques suited to their particular topological queries and available resources. 
 
purple_lock_openEmbRS a new two-component system that inhibits biofilm formation and saves Rubrivivax gelatinosus from sinking Anne Soisig Steunou, Sylviane Liotenberg, Marie-Noêlle Soler, Romain Briandet, Valérie Barbe, Chantal Astier and Soufian Ouchane 
 
Summary: Ability of the photosynthetic bacterium Rubrivivax gelatinosus to form biofilm. The EmbRS two-component system inhibits biofilm formation. Growth of the EmbRS mutant results in the formation of conspicuous bacterial veils around the toothpick scaffolds. 
 
 

Food Science & Nutrition – Issue 1:2 now live!

Food Science & Nutrition CoverYou can read Issue 1:2 of Food Science & Nutrition online now!

The journal publishes articles relating to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.  Food Science & Nutrition is an open access, fully peer-reviewed journal providing rapid dissemination of research in all areas of food science and nutrition. 

Read all our open access articles online here>

Below are some top articles which Editor-in-Chief Dr. Y. Martin Lo has highlighted from the second issue.

purple_lock_openNoni juice reduces lipid peroxidation–derived DNA adducts in heavy smokers
Mian-Ying Wang, Lin Peng, Claude J. Jensen, Shixin Deng and Brett J. West

Summary: A double-blind, placebo-controlled clinical trial revealed that noni juice may reduce lipid peroxidation–derived DNA adducts in the lymphocytes of heavy smokers. This effect is associated with antioxidant activity of noni juice and the presence of iridoids, the major phytochemical constituents of noni fruit.

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Summary: Intact starch granules are an interesting stabilizer candidate for food grade Pickering emulsions. The stabilizing capacity of seven different intact starch granules for making oil-in-water emulsions has been the topic of this screening study. Among all types of starch studied quinoa had the predominantly best emulsifying properties and surprising long term stability over 2 years of storage.

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MicrobiologyOpen Publishes Issue 2:1

MicrobiologyOpenThe latest issue of MicrobiologyOpen is available online now! 16 new articles are fully open access: free to read, download and share.

Below are some top articles highlighted by the Editor-in-Chief, Pierre Cornelis:

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Summary: In this article we provide the first genetic characterization of syntrophic acetate-oxidizing bacteria (SAOB) being able to make a living close to the thermodynamic equilibrium. To understand the fundamental biochemical and regulatory mechanisms behind syntrophic acetate oxidation, we identified the respective formyltetrahydrofolate synthetase gene (fhs), encoding a key enzyme of the Wood–Ljungdahl pathway used by these organisms under heterotrophic and syntrophic growth conditions. We further investigated fhs mRNA expression and analyzed the surrounding gene structures.
 
purple_lock_openSa-Lrp from Sulfolobus acidocaldarius is a versatile, glutamine-responsive, and architectural transcriptional regulator Amelia Vassart, Marleen Van Wolferen, Alvaro Orell, Ye Hong, Eveline Peeters, Sonja-Verena Albers and Daniel Charlier
 
Summary: The Lrp-like regulator Sa-Lrp binds in a glutamine-dependent manner to AT-rich binding sites and induces bending and wrapping upon binding. Furthermore, by analyzing an Sa-lrp deletion mutant, we demonstrate that the protein affects transcription of some of the genes of which the promoter region is targeted and that it is an important determinant of the cellular aggregation phenotype. Therefore, Sa-Lrp is a glutamine-responsive global transcriptional regulator with an additional architectural role.
 
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Cell-free production of integral membrane aspartic acid proteases reveals zinc-dependent methyltransferase activity of the Pseudomonas aeruginosa prepilin peptidase PilD Khaled A. Aly, Emily T. Beebe, Chi H. Chan, Michael A. Goren, Carolina Sepúlveda, Shin-ichi Makino, Brian G. Fox and Katrina T. Forest
 
Summary:  The integral membrane aspartic acid protease PilD was synthesized in a cell-free translation system, as was its full-length substrate, PilA. The purified enzyme displayed both of its known biochemical activities: cleavage of the PilA signal peptide and S-adenosyl methionine-dependent methylation of the mature PilA. We show that PilD is a zinc binding protein, and zinc is required for the methylation activity but not the peptidase activity of PilD.
 
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Summary: The data strongly suggest that at least four transcription factors (AtfB,SrrA,AP-1, and MsnA) participate in the regulatory network that induces aflatoxin biosynthesis as part of the cellular response to oxidative stress in Aspergillus parasiticus.