Cancer Medicine Publishes Issue 2:1

Cancer Medicine

You can read Issue 2:1 of Cancer Medicine online now!

The journal brings together articles on a range of oncology specialties, covering cancer biology, clinical cancer research and cancer prevention, with authors from across the globe.

Below are some top articles which Editor-in-Chief Prof. Qingyi Wei has highlighted from the issue.  We hope that you enjoy this exciting new content.

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Optimization of routine KRAS mutation PCR-based testing procedure for rational individualized first-line-targeted therapy selection in metastatic colorectal cancer
Anne-Sophie Chretien, Alexandre Harlé, Magali Meyer-Lefebvre, Marie Rouyer, Marie Husson, Carole Ramacci, Valentin Harter, Pascal Genin, Agnès Leroux and Jean-Louis Merlin

Summary: We performed our study with three techniques (TaqMan, HRM and PCR-RFLP) on 674 paraffin embedded tumors specimens and processed retrospectively discrepancies with a fourth one (CE-IVD COBAS 4800 KRAS mutation test).The main finding of this study is to propose a routine scheme for the determination of KRAS mutations in colorectal cancers ensuring high specificity and appropriate delay for first line prescription of anti-EGFR antibodies.

purple_lock_openTargeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases
Heike Niessner, Andrea Forschner, Bernhard Klumpp, Jürgen B. Honegger, Maria Witte, Antje Bornemann, Reinhard Dummer, Annemarie Adam, Jürgen Bauer, Ghazaleh Tabatabai, Keith Flaherty, Tobias Sinnberg, Daniela Beck, Ulrike Leiter, Cornelia Mauch, Alexander Roesch, Benjamin Weide, Thomas Eigentler, Dirk Schadendorf, Claus Garbe, Dagmar Kulms, Leticia Quintanilla-Martinez and Friedegund Meier

Summary: In patients with metastatic melanoma, brain metastases are the most common cause of death. Our findings suggest that hyperactivation of the AKT survival pathway in melanoma brain metastases promotes the survival and drug resistance of melanoma cells in the brain parenchyma. Inhibition of this pathway thus has potential as a novel strategy for the treatment of melanoma brain metastases.

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A safe and effective dose of cisplatin in hepatic arterial infusion chemotherapy for hepatocellular carcinoma
Akihiko Osaki, Takeshi Suda, Kenya Kamimura, Atsunori Tsuchiya, Yasushi Tamura, Masaaki Takamura, Masato Igarashi, Hirokazu Kawai, Satoshi Yamagiwa and Yutaka Aoyagi

Summary: An excess dose of cisplatin in hepatic arterial infusion chemotherapy for hepatocellular carcinoma may enhance rapid tumor growth in case of resistance to cisplatin. A relationship between cisplatin dose and a tumor growth rate suggests that cisplatin (mg) should not be applied more than creatinine clearance (mL/min/1.73 m2) especially when it is not clear whether a target of HCC is sensitive or resistant to cisplatin, and the targeted liver volume should be smaller than 200 times of the CDDP dose (mg).

Cancer Medicine is a peer reviewed, interdisciplinary journal providing rapid publication of cutting-edge research from global biomedical researchers across the cancer sciences.

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Read the First Issue of Food Science & Nutrition Online Now!

Food Science & Nutrition CoverWe are delighted to announce that Food Science & Nutrition has published its first issue, now freely available to read onlineFood Science & Nutrition opened for submissions in May 2012 and since then has received a high number of submissions relating to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.  Food Science & Nutrition is an open access, fully peer-reviewed journal providing rapid dissemination of research in all areas of food science and nutrition.  Read all our open access articles online here>

Below are some top articles which Editor-in-Chief Dr. Y. Martin Lo has highlighted from the inaugural issue.

purple_lock_openComparative lethality kinetic curves and predictive models of F-value for Listeria monocytogenes using different sanitizers
Cezar A. Beltrame, Gabriela B. Kubiak, Ieda Rottava, Geciane Toniazzo, Rogério L. Cansian, Lindomar A. Lerin, Débora de Oliveira and Helen Treichel
Summary: The results obtained in the present work are of industrial importance and not available in the current literature, mainly for organic acids. The results obtained are of fundamental importance in terms of industrial strategy for sanitization procedure, permitting to choose the best relation product concentration/exposure time, aiming at reducing costs without compromising the disinfectant efficiency.

purple_lock_openGenetic characterization of Italian tomato varieties and their traceability in tomato food products
Maria Luisa Savo Sardaro, Marta Marmiroli, Elena Maestri and Nelson Marmiroli
Summary: DNA molecular markers can effectively describe the genetic diversity existing among tomato cultivars and landraces, providing tools for traceability in the whole food supply chain. Microsatellite markers can identify tomato genotypes in raw matter and in processed products.

purple_lock_openCinnamon extract inhibits angiogenesis in zebrafish and human endothelial cells by suppressing VEGFR1, VEGFR2, and PKC-mediated MAP kinase
Rishipal R. Bansode, TinChung Leung, Priscilla Randolph, Leonard L. Williams and Mohamed Ahmedna
Summary: In this study, the antiangiogenic properties of cinnamon extract is demonstrated in zebrafish model. Cinnamon extract’s effect is mediated by inducing PKC-specific phosphorylation of MAPK signaling.

We hope that enjoy reading this issue. 

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Cancer Medicine Publishes Issue 1:3

Cancer Medicine

You can read Issue 1:3 of Cancer Medicine online now!

The journal brings together articles on a range of oncology specialties, covering cancer biology, clinical cancer research and cancer prevention, with authors from across the globe.

Below are some top articles which Editor-in-Chief Prof. Qingyi Wei has highlighted from the issue.  We hope that you enjoy this exciting new content.

purple_lock_openModulation of CXCL-8 expression in human melanoma cells regulates tumor growth, angiogenesis, invasion, and metastasis
Sheng Wu, Seema Singh, Michelle L. Varney, Scott Kindle and Rakesh K. Singh

Summary: CXCL-8 is a direct determinant of aggressive melanoma phenotypes, including tumor growth, metastasis, and angiogenesis, and targeting CXCL-8 produced by tumor cells and the supporting stroma is a direction for studying this pathway to develop future melanoma diagnostics and therapeutics.

purple_lock_openEffectiveness of aromatase inhibitors and tamoxifen in reducing subsequent breast cancer 
Reina Haque, Syed A. Ahmed, Alice Fisher, Chantal C. Avila, Jiaxiao Shi, Amy Guo, T. Craig Cheetham and Joanne E. Schottinger

Summary: Women who take aromatase inhibitors (AIs) alone or following tamoxifen treatment have subsequent breast cancer rates similar to women treated exclusively with tamoxifen even after accounting for adherence.

purple_lock_openUrban–rural disparities in colorectal cancer screening: cross-sectional analysis of 1998–2005 data from the Centers for Disease Control’s Behavioral Risk Factor Surveillance Study 
Allison M. Cole, J. Elizabeth Jackson and Mark Doescher

Summary: Colorectal cancer screening is effective, yet underused. Rural residents may face increased barriers to screening compared with urban residents. We describe significant urban–rural colorectal cancer screening disparities in the United States.

Cancer Medicine is a peer reviewed, interdisciplinary journal providing rapid publication of cutting-edge research from global biomedical researchers across the cancer sciences.

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Food Science & Nutrition Publishes its First Articles on Early View

Food Science & Nutrition CoverWe are delighted to announce that Food Science & Nutrition has published its first articles on Early View.  Food Science & Nutrition opened for submissions in May 2012 and we have received a high number of submissions related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.  The first articles are now live on Wiley Online Library. Read all our open access articles here!  Food Science & Nutrition is an open acces, fully peer-reviewed journal providing rapid dissemination of research in all areas of food science and nutrition.

We hope that next time your are preparing a manuscript you will consider submitting to the journal. Among the first papers available online are:

purple_lock_open Supplementing long-chain n-3 polyunsaturated fatty acids in canned wild Pacific pink salmon with Alaska salmon oil by Trina J. Lapis, Alexandra C. M. Oliveira, Charles A. Crapo, Brian Himelbloom, Peter J. Bechtel and Kristy A. Long
Abstract: Establishing n-3 polyunsaturated fatty acid contents in canned wild Alaska pink salmon products is challenging due to ample natural variation found in lipid content of pink salmon muscle. Supplementing canned wild Alaska pink salmon with salmon oil reduces variability in product composition, and this facilitates accurate disclosure of the n-3 fatty acid content per serving size in the product package.

purple_lock_open Effects of agriculture production systems on nitrate and nitrite accumulation on baby-leaf salads by Alfredo Aires, Rosa Carvalho, Eduardo A. S. Rosa and Maria J. Saavedra
Abstract: We studied the effect of agricultural practices on toxic compounds accumulation. Nitrates and nitrites were detected at lower levels, within the EC regulations. Benefits of ready-to-eat vegetables consumption are discussed.

If you would like to know when new articles and issues appear online sign up for eToC alerts on the Food Science & Nutrition website >