“A leading genomic scientist has called on people who have their DNA analysed to make the full results openly available “for the greater public good”. …While conceding that “open access to genome sequences is not for everyone”, he hoped that many people would donate their genomes openly to science once they understood the risks and benefits….”
“In the longer-term future, one could envision a system where researchers post their scientific contributions; a paper, a single figure, a method, a hypothesis; where we have the potential to make smaller contributions to the global knowledge base and get credit for those contributions in a manner that is more rapid and incremental. This would allow multiple scientists to collaborate and contribute to what we now know of as a single paper. Part of the challenge of the next 10 years is the problem of increasing information overload. Journals in the life sciences are aware that preprints have been around in physics for 25 years, and that the existence of preprints do not diminish the need for journals in that field. It is already impossible for a person to read all the relevant literature in their area, and this will only get harder. We need better tools to read and comprehend the literature, and a lot of these tools will be given by innovations in software and machine learning. My hope is that more of the literature is accessible to text and data mining, which will enhance our ability to understand the literature beyond that of a single human reader….”
“The sequence of the human genome, completed in 2001, was supposed to quickly reveal the secrets of health and disease. Instead, it showed that human bodies are more complicated than anyone realized. Disease is usually caused not by one bad gene, but by subtle variations in dozens or hundreds of genes working with and against each other in vast networks.
This discovery delivered a reality check to genome scientist Eric Schadt. Pharmaceutical giant Merck had spent hundreds of millions of dollars…”
“The Health Research Alliance, a collaborative member organization of nonprofit research funders, is committed to maximizing the impact of biomedical research to improve human health….The HRA partnered with the National Library of Medicine (NLM) to enable HRA member-funded awardees to deposit their publications into PubMed Central (PMC) with an embargo no longer than 12 months….”
“Drug discovery resources in academia and industry are not used efficiently, to the detriment of industry and society. Duplication could be reduced, and productivity could be increased, by performing basic biology and clinical proofs of concept within open access industry-academia partnerships. Chemical biologists could play a central role in this effort….In summary, the development of new medicines is being hindered by the way in which academia and industry advance innovative targets. By generating freely available chemical and clinical probes and performing open-access science, the overall system will produce a wider range of clinically validated targets for the same total resource. This is arguably the most effective way to spur the development of treatments for unmet needs.”
“The drug discovery process is losing productivity to the detriment of the global economy and human health. The greatest productivity gains in the sector can be achieved by solving the fundamental scientific problems limiting the progression of compounds through clinical trials. These problems must be addressed through a combination of ‘blue sky’ and targeted research on priority issues, perhaps defined within a ‘grand challenges’ framework. For many reasons, targeted research should be performed in PPPs [public–private partnerships] that release information into the public domain immediately, with no restriction on use.”
“The SGC is engaged in pre-competitive research to facilitate the discovery of new medicines. As part of its mission the SGC is generating reagents and knowledge related to human proteins and proteins from human parasites. The SGC believes that its output will have maximal benefit if released into the public domain without restriction on use, and thus has adopted the following Open Access policy.
The SGC and its scientists are committed to making their research outputs (materials and knowledge) available without restriction on use. This means that the SGC will promptly place its results in the public domain and will not agree to file for patent protection on any of its research outputs. It will seek the same commitment from any research collaborator….”
“On May 23-24, 2017, the Association for the promotion of open science in Haiti and in Africa (Apsoha) and the Yaoundé Higher institute of medical technology (ISTM) with support from the international network Open Science Hardware (Gosh), organized in the Cameroonian capital the first seminar dedicated to biohacking and open hardware equipment in healthcare: ‘Biohacking in the medical field: perspectives for developing countries’. On the first day were presented the different advances, uses and applications of DIYbio in the medical field. The second day was dedicated to workshops where participants had to apply and contextualize acquired knowledge.”