About Open Science | Montreal Neurological Institute and Hospital – McGill University

“The Montreal Neurological Institute and Hospital becomes the first Open Science Institute in the world.

Open Science is a no-barrier approach to scientific research that is gaining ground within the academic community. Its principles are simple: allow research data and materials to move freely from one research team to another, between disciplines and toward the creation of innovative businesses….

MNI researchers will render all positive and negative numerical data, models used, data sources, reagents, algorithms, software and other scientific resources publicly available no later than the publication date of the first article that relies on this data or resource….

Subject to patient confidentiality and informed consent given, neither the MNI nor its researchers in their capacity as employees or consultants of the McGill- MNI unit will obtain patent protection or assert data protection rights in respect of any of their research….”

How Canada can lead the world in innovating innovation – The Globe and Mail

“Beyond these policies, Canadians are experimenting with innovation models that build cross-sectoral collaboration, lower barriers to working together, and that create excitement and tangible know-how that attract firms and investments to Canada. The Montreal Neurological Institute and Hospital (the “Neuro”) is the world leader – in co-operation with Toronto Structural Genomics Consortium – in creating a new model of innovation called open science. This model builds on what worked in artificial intelligence: an open platform that creates community, lessens transaction costs and builds excitement. The rest of the world is coming to Montreal to learn from the Neuro’s experiment. Research institutions, governments and firms want to learn how we did it and want to take part. Students and researchers come to Montreal because of the Neuro’s open science platform. And over the last year, the Institute gained the two largest philanthropic donations in its history….”

The onward march of open science | The Horizons Tracker

“The increasingly open and transparent nature of academic research is something I’ve touched upon many times on this blog in recent years.  Further evidence of this general trend has emerged via the launch of MNI Open Research, a new platform for the publication of neuroscience research.

The platform aims to facilitate open and transparent peer-review, with all of the data used in the studies published, including null results, so that other researchers can avoid duplication, and also test the replicability of research.”

Open Science: The Next Frontier for Neurology

“What are One Mind’s open science principles?

To support Open Science for brain disease and injury, One Mind urges the international research community to adopt the following principles:

Provide informed consents for collection of medical data obtained from patients, which should permit use of their de-identified (anonymous) data for research related to a broad range of conditions — consistent with protecting patient privacy.

Use widely accepted common data elements and conform to the highest possible standards when clinical data is collected. This enables it to be used by the widest possible array of users, whether academic, medical, clinical or commercial.

Make data available to the research community as soon as possible after study completion, with the goal of opening data access within six months whenever possible.

Make data accessible to external researchers during the course of a study (subject to relevant data use agreements).

Give data generators proper attribution & credit from those who use their data.

Do not delay the publication of findings, as it may affect patient care.

Intellectual property should not stand in the way of research, but be used to incentivize material participation….”

Understanding the cellular and molecular alterations in PTSD brains: The necessity of post-mortem brain tissue: European Journal of Psychotraumatology: Vol 8, No 1

Abstract:  The personal, social and economic burden of post-traumatic stress disorder (PTSD) is high and therapeutic approaches are only partially effective. Therefore, there is an urgent need to understand the cellular and molecular alterations in PTSD brains in order to design more effective treatment strategies. Although brain imaging strategies have considerably improved our understanding of PTSD, these strategies cannot identify molecular and cellular changes. Post-mortem examination of the brain is a crucial strategy to advance our understanding of the underlying neuropathology, neurochemistry and molecular pathways of PTSD. Unfortunately, there is a worldwide serious shortage of human psychiatric brain tissue available for post-mortem research. Therefore, the Netherlands Brain Bank launched a prospective donor programme to recruit brain donors with psychiatric diseases in 2012: Netherlands Brain Bank for Psychiatry (NBB-Psy). NBB-Psy aims to establish a resource of brain tissue of seven psychiatric disorders: post-traumatic stress disorder, major depressive disorder, schizophrenia, bipolar disorder, obsessive-compulsive disorder, autism spectrum disorder, and attention-deficit hyperactivity disorder. Participants of several large and clinically characterized research cohorts of psychiatric patients, including relatives and controls, were asked prospectively to register as brain donors. Registered donors complete medical questionnaires annually. The number of registered donors with a psychiatric disorder at the NBB has risen from 312 (most of which were patients with major depressive disorder) in the year 2010 to 1187 in 2017, of which 146 are PTSD patients. The NBB guarantees worldwide open access to biomaterials and data. Any researcher affiliated with a research institute can apply.

Wiley partners with the British Journal of Surgery society to launch new open access journal | Wiley News Room – Press Releases, News, Events & Media

“Wiley has partnered with the British Journal of Surgery society to launch an exciting new open access title, BJS Open. Like its sister title, British Journal of Surgery (BJS), BJS Open will publish high-quality work on all aspects of general surgery and related topics.”

George Church, Lumosity want those with good memory to ‘share it, not hoard it’ – Boston Business Journal

“Harvard researcher George Church is looking for people with exceptionally good memory to take part in a study aimed at finding genetic mechanisms that boost memory in research that could one day result in better drugs or diagnostic tests….“Our goal is to get people who have remarkable memory traits and engage them in the PGP. If you are exceptional in any way, you should share it, not hoard it,” said George Church….The goal is to recruit 10,000 members who have already participated in Harvard’s Personal Genome Project, an open research project started in 2005 in which individuals shared their genome sequences, biospecimens and health care data for unrestricted research….”

Open Access Dataset for EEG+NIRS Single-Trial Classification – IEEE Xplore Document

Abstract:  We provide an open access dataset for hybrid brain-computer interfaces (BCIs) using electroencephalography (EEG) and near-infrared spectroscopy (NIRS). For this, we con-ducted two BCI experiments (left vs. right hand motor imagery; mental arithmetic vs. resting state). The dataset was validated using baseline signal analysis methods, with which classification performance was evaluated for each modality and a combination of both modalities. As already shown in previous literature, the capability of discriminating different mental states can be en-hanced by using a hybrid approach, when comparing to single modality analyses. This makes the provided data highly suitable for hybrid BCI investigations. Since our open access dataset also comprises motion artifacts and physiological data, we expect that it can be used in a wide range of future validation approaches in multimodal BCI research.


“Brain Research through Application of Innovative Neuro-technologies [BRAIN] Initiative- The Committee continues to strongly support the BRAIN initiative. The bill provides $250,000,000, an increase of $100,000,000 above fiscal year 2016, to expand the initiative consistent with the BRAIN 2025 report issued in 2014. The Committee is encouraged by the rapid progress the initiative has made in dramatically changing the ways we gather data about the brain, generating advances in tools for measuring brain structure and activity that have the potential to produce massive amounts of new data. To prepare for the management of all this information, BRAIN has dedicated some of its existing budget to stimulate the development of centers for data warehousing, analysis and visualization for each of its defined research areas. However, the Committee believes the need for data integration and manipulation that would make full use of these large cross-disciplinary datasets not only entails a large investment in open data hosting, but also requires significant investments in interactive data management that combines neurophysiological, imaging, clinical, and molecular datasets in both human and model organisms. The Committee encourages NIH to work with its Federal, academic and private partners, as well as leaders in the technology sector, to jointly develop integrated, user friendly, scalable data analysis hubs for BRAIN data as well as methods for tool dissemination. The goal of such an effort would be a network that has at its core an interconnected open platform of imaging, neurophysiological, behavioral, clinical, and molecular data along with the metadata essential for its interpretation. This collaborative effort would guide development and sharing of best practices in data acquisition, analysis, and choices in computational pipelines. Open sharing on this scale would enable data analysis and visualization across institutional boundaries to accelerate understanding of brain function and dysfunction. The Committee directs NIH to provide a plan, developed in collaboration with its partners, to the Committee 6 months after enactment of this act to create such a network, including schedule and cost estimates….

Open Access to Federal Research- The Committee has received reports by the Office of Science and Technology Policy’s [OSTP] on the progress of all Federal agencies in developing and implementing policies to increase public access to Federally funded scientific research. The Committee is pleased by the progress, but previously instructed OSTP to have plans approved from all relevant Departments’ and Agencies’ plans in this act’s jurisdiction approved by the end of calendar year 2014 with implementation occurring by January 1, 2016. Agencies funded in this act are instructed to continue providing quarterly reports to the Committees on Appropriations of the House of Representatives and Senate to keep Congress apprised of the remaining progress needed to make federally funded research accessible to the public as expeditiously as possible….

Open Textbooks- The Committee directs the Department to provide a report to the Committee no later than 180 days after enactment of this act on steps it has taken or plans to take to help achieve the highest level of savings possible for students through the sustainable, expanded use of open textbooks at institutions of higher education and production of the highest quality open textbooks….”