Latest Article Alert from Reproductive Health

The latest articles from Reproductive Health, published between 27-Aug-2012 and 26-Sep-2012

For articles which have only just been published, you will see a ‘provisional PDF’ corresponding to the accepted manuscript.
A fully formatted PDF and full text (HTML) version will be made available soon.

Procuring family planning methods for every woman in the world
Smith R, Belizán JM

Latest Article Alert from BMC Public Health

The latest articles from BMC Public Health, published between 19-Sep-2012 and 26-Sep-2012

For articles which have only just been published, you will see a ‘provisional PDF’ corresponding to the accepted manuscript.
A fully formatted PDF and full text (HTML) version will be made available soon.

Study protocol
Web-based screening and brief intervention for poly-drug use among teenagers: study

Women’s Health and Fitness Series Part V: Pregnancy

In this last post of the Women’s Health and Fitness Series, we delve into the mother of all topics: pregnancy. As one of the few health topics that truly only affects women, pregnancy is highly stressful on for women’s bodies, but amazingly, they know exactly how to respond to this event. In addition, many of the issues previously raised in the series continue to carry weight when discussing pregnancy.

One aspect of pregnancy that carries a lot of weight is exactly that: the amount of weight a pregnant woman gains. Obesity in pregnancy is associated with a long list of medical complications for a mother and child, including gestational diabetes, pre-eclampsia, infection and many others.  A PLOS ONE study published in July 2012 investigates the link between healthy weight during pregnancy and the associated risks when the term “eating for two” is taken too liberally. Obesity in pregnancy is associated with a long list of medical complications for a mother and child, including gestational diabetes, pre-eclampsia, infection and many others.

The authors, from the University of Ulster in Ireland, wanted to see if regimented diet and physical activity was an efficient intervention to reduce excess gestational weight gain (GWG). They reviewed 5 studies that had examined a total of 971 pregnant women with a mean BMI of 26. They found that setting goals through 1-on-1 diet and lifestyle counseling was the most successful strategy to help women gain appropriate amounts of weight during pregnancy. The researchers also note that while weight is a primary concern, and behavior modification is an effective way to address the problem, more research is required “to target women’s psychological needs as well as their emotional and physical needs”.

Pregnancy is a unique experience for the female gender, as well as for each individual woman.  Much like we’ve discussed throughout the series, health incorporates a balance of many factors, like nutrition, weight, emotional well-being, and should be tailored to each person.

With that, happy Women’s Health and Fitness Day, and we hope this month’s series has been informative and inspirational!

Image Credit: makelessnoise on Flickr CC-by license

Citation: Brown MJ, Sinclair M, Liddle D, Hill AJ, Madden E, et al. (2012) A Systematic Review Investigating Healthy Lifestyle Interventions Incorporating Goal Setting Strategies for Preventing Excess Gestational Weight Gain. PLoS ONE 7(7): e39503. doi:10.1371/journal.pone.0039503





SCOAP3 Gold OA "Membership": Unnecessary, Unscalable & Unsustainable

1. High Energy Physics (HEP) already has close to 100% Open Access (OA): Authors have been self-archiving their articles in Arxiv (both before and after peer review) since 1991 (“Green OA”).

2. Hence SCOAP3 is just substituting the payment of consortial “membership” fees for publishing outgoing articles in place of the payment of individual institutional subscription fees for accessing incoming articles in exchange for an OA from its publisher (“Gold OA”) that HEP already had from self-archiving (Green OA).

3. As such, SCOAP3 is just a consortial subscription price agreement, except that it is inherently unstable, because once all journal content is Gold OA, non-members are free-riders, and members can cancel if they feel a budget crunch.

4. Nor does membership scale to other disciplines.

5. High Energy Physics would have done global Open Access a better service if it had put its full weight behind promoting (Green OA) mandates to self-archive by institutions and research funders in all other disciplines.

6. The time to convert to Gold OA is when mandatory Green OA prevails globally across all disciplines and institutions.

7. Institutions can then cancel subscriptions and pay for peer review service alone, per individual paper, out of a portion of their windfall cancelation savings, instead of en bloc, in an unstable (and overpriced) consortial “membership.”

How Open Is It? Draft Document for Open Access- Feedback Please!

Not all Open Access is created equal. To move beyond the seemingly simple question of “Is it Open Access?” PLOS, SPARC and OASPA have collaborated to develop a resource called “HowOpenIsIt?” This resource identifies the core components of open access (OA) and how they are implemented across the spectrum between “Open Access” and “Closed Access”. We recognize there are philosophical disagreements regarding OA and this resource will not resolve those differences. 
We are seeking input on the accuracy and completeness of how OA is defined in this guide. Download the open review draft and provide feedback below in the comment form on SPARC’s website. In its final form, this guide will provide an easily understandable, comprehensive, and quantifiable resource to help authors make informed decisions on where to publish based on publisher policies.
With this guide we aim to provide greater clarity regarding its definition and components. All suggestions will be considered and a final version will be released during Open Access Week (October 22 -28, 2012). The comment period will close on Monday, October 8, at 5:00pm (EST).

Woman’s Health and Fitness Series IV: Ovarian Cancer

In the last few weeks, we have discussed a range of topics that influence woman’s health and fitness, including obesity, cardiovascular disease and anorexia.  Today, in honor of Ovarian Cancer Awareness Month, we would like to share some research about ovarian cancer, a disease that affects 20,000 women in the United States every year.  In order to best treat and understand the causes of ovarian cancer, researchers continue to dig deeper into this serious woman’s health issue.

For example, we are aware that our environment affects our health, but did you know that the environment your grandmother lived in could affect you as well? This year, researchers at Washington State University published a study in PLOS ONE that found that ovarian cancer may result from previous generations’ exposure to environmental chemicals.  The researchers exposed pregnant rats to various compounds, including a fungicide, a pesticide mixture, a plastic mixture, dioxin, and a hydrocarbon mixture, to investigate the role of environmental exposure in ovarian disease.  They found that the compounds caused epigenetic changes, which are chemical modifications to DNA that affect how the DNA is used in a cell. In both the first and third generations, the results showed significant impact after the toxin exposure.

This study helped further our understanding of the causes of ovarian disease, but what about the treatment?  In another PLOS ONE article published this year, researchers studied the defects in DNA repair pathways in sporadic ovarian carcinomas, a particular type of ovarian cancer, which may influence the effectiveness of treatment.  Through this investigation, the researchers concluded that patients with high levels of three specific proteins were at a higher risk for treatment resistance and cancer reoccurrence.  This finding may have important implications for ovarian cancer diagnosis as well as treatment.

Diagnosis of this disease is particularly important, because treatment is most effective when it is diagnosed in its early stages.  In the spirit of Women’s Health and Fitness Day and Ovarian Cancer Awareness Month, it is important to remember the impact our environment has on our health, as well as the importance of early disease detection.

Please remember to check in later this week for our last blog post of our Women’s Health and Fitness Series, where we will discuss pregnancy.

Citation: Nilsson E, Larsen G, Manikkam M, Guerrero-Bosagna C, Savenkova MI, et al. (2012) Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease. PLoS ONE 7(5): e36129. doi:10.1371/journal.pone.0036129

Citation: Wysham WZ, Mhawech-Fauceglia P, Li H, Hays L, Syriac S, et al. (2012) BRCAness Profile of Sporadic Ovarian Cancer Predicts Disease Recurrence. PLoS ONE 7(1): e30042. doi:10.1371/journal.pone.0030042

Image Credit: cc-by license by Summer Skyes 11 on Flickr.

Latest Article Alert from Breast Cancer Research

The latest articles from Breast Cancer Research, published between 09-Sep-2012 and 23-Sep-2012

For research articles that have only just been published you will see a ‘provisional PDF’ corresponding to the accepted manuscript. Fully formatted PDF and full-text (HTML) versions will be made available soon.

Integration of ER?-PELP1-HER2 signaling by LSD1 (KDM1A/AOF2) offers combinatorial